This lecture course, accompanied by a practical exersise, is being offered in winter semester. It is suitable for bioinformatics students of the 5th semester and higher.
- Structural bioinformatics (Methods of biochemical analysis, v.44). Bourne, P. and Weissig, H., editors. Wiley-Liss, 2003.
- Lesk, A.. Introduction to Protein Architecture: The Structural Biology of Proteins. Oxford University Press, 2001.
- Branden, C.I. & Tooze, J. Introduction to Protein Structure: Second Edition. Routledge, 1999.
- Zvelebil, M. and Baum, J. Introduction to bioinformatics. Garland Science, 2007.
- Mount, D. Bioinformatics: Sequence and Genome Analysis. Cold Spring Harbor Laboratory Press; 2 edition, 2004.
List of topics
- Introduction to structural bioinformatics
- Protein structure
- Molecular visualization
- Secondary structure assignment
- Structure determination
- Structure quality
- Structural databases
- Structure comparison
- Identification of structural domains
- Structure classification
- Protein structures: an overview
- Protein folding
- Homology modeling
- Secondary structure prediction
- Transmembrane region prediction
- Coiled coils
- Low complexity, non-globular, and disordered regions
- Signal peptides
- Contact prediction
- Genomes and folds
- Target selection
- Extreme environment
- Protein-protein interactions
- Protein evolution
- Structure-function relationships in proteins
- Functionally important residues
- Local sequence motifs
- Exons and domains
- Alternative splicing and protein structure
- Mutations and their effect on structures
- Structure design